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KMID : 0357920050390040222
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Korean Journal of Pathology
2005 Volume.39 No. 4 p.222 ~ p.228
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An Analysis of p53, bcl-2 and Ki-67 Expressions, and Apoptosis in Rectal Cancer: Their Correlation with the Tumor Response after Preoperative Radiochemotherapy
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Yoo Jin-Young
Kim Sung-Hwan
Chun Chung-Soo
Kang Chang-Suk
Chin Hyung-Min
Kang Seok-Jin
Kim Su-Zy
Cho Hyeon-Min
Kim Jun-Ki
Lee Jung-Yong
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Abstract
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Background: Preoperative radiochemotherapy (RCT) has been administered for locally advanced rectal cancer to increase the therapeutic benefits, and to preserve the sphincter in low-lying tumors, however, tumor responses after RCT are variable.
Methods: Apoptotic index (AI), and expressions of Ki-67, p53 and bcl-2 were analyzed in pretreatment biopsies from 69 patients with rectal cancer by immunohistochemistry. Tumor response was graded in surgically resected specimens by using a three-scale grading system: no response (NR), partial remission (PR) and complete remission (CR).
Results: CR was identified in 19 cases (28%), PR in 24 cases (35%), and NR in 26 cases (38%) of 69 cases. p53 protein was expressed in 49 cases (71%), whereas bcl-2 was in 42 cases (61%). The pretreatment Ki-67 labeling index was 65.4±23.4%. The tumor response was not associated with any of these markers. Tumors with CR/PR showed a higher AI (0.84±0.84%/0.66±0.52%) than that of tumors with NR (0.58±0.54%). There was a significant correlation between tumor response and the histologic differentiation (p=0.008) or recurrence (p=0.039).
Conclusions: The AI revealed a tendency to increase in tumors with CR/PR, while expressions of p53 and bcl-2, and Ki-67 labeling index had little direct association with tumor response.
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KEYWORD
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Rectal neoplasms, Protein, p53, bcl-2 protein antigen, Ki-67 protein antigen, Apoptosis
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